Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma
EDIT will develop advanced transformative technology combining newly developed targeted imaging technologies (high-resolution ultrasound elastography and photoacoustic imaging) on the bladder using plasmonic gold sensors for enhanced resolution.
Structural and mechanical modification of the collagen rich extracellular matrix is a common denominator for invasive breast, colorectal, prostate and bladder cancers.
The EDIT platforms will also pave the ways for the earlier management of other bladder-related pathologies and solid tumors, with a profound impact on the quality of life and well-being of millions
The EDIT approach exploits the structural and mechanical properties of the bladder extracellular matrix (ECM) as a unique biomarker of the early onset/progression/relapse of carcinoma, through engineered novel gold nanorods (GNRs) used as intravesical photoacoustic antennas targeted at the ECM within the cellular microenvironments and consequently generating an ad hoc visualization platform. GNRs will be further utilized as heat-releasing effectors at nanoscale for targeted cancer photo-thermal therapy.
EDIT is designed to detect pre-neoplastic area and eradication of local areas at few cells resolution with high sensitivity and specificity.
EDIT Outcomes will revolutionize the management of BCa with the introduction of sensing and effector nanotechnologies combined with non-invasive organ imaging with high resolution/definition 3D ultrasound and photoacoustic imaging.